A recent meta-analysis of 11 randomized controlled trials on the effectiveness of PEA supplementation in participants suffering from chronic pain due to a variety of conditions including spinal cord injury, endometriosis, irritable bowel syndrome (IBS), carpal tunnel syndrome, temporomandibular joint arthritis (TMJ), vestibulodynia, burning mouth syndrome, diabetic neuropathy, knee osteoarthritis, dysmenorrhea, and regular use of injectable medications for multiple sclerosis showed that PEA may be an effective and well-tolerated treatment for chronic pain.
Lang-Illievich K, Klivinyi C, Lasser C, Brenna CTA, Szilagyi IS, Bornemann-Cimenti H. Palmitoylethanolamide in the Treatment of Chronic Pain: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials. Nutrients. 2023;