PEA

Palmitoylethanolamide (PEA) is an endogenous (produced in the body) omega-7 fatty acid amide and is a cannabimimetic compound with unique properties.

Quick facts

  • PEA is an effective and well-tolerated alternative for the treatment of chronic pain

WHAT IS PEA USED FOR?

PEA is known for its ability to reduce chronic and neuropathic pain by modulating the inflammatory response and acting on the endocannabinoid system.

Types of pain that PEA helps manage:

  • Inflammatory pain: arthritis, osteoarthritis, menstrual pain, abdominal and pelvic pain typical of endometriosis, inflammatory bowel disease, or multiple sclerosis.
  • Neuropathic pain: diabetic neuropathy, post-chemotherapy treatment neuropathy, lower back pain, sciatica, or post-herpetic neuralgia.
  • Mixed pain (inflammatory + neuropathic): irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, polymyalgia rheumatica.

DID YOU KNOW...

Virtually everyone can take ZeroDol. There are no conditions, illnesses, or prescribed medications that contraindicate the use of the omega-7 fatty acid PEA.

Clinical Studies

PEA: Natural pain reliever for everyone

A recent meta-analysis of 11 randomized controlled trials on the effectiveness of PEA supplementation in participants suffering from chronic pain due to a variety of conditions including spinal cord injury, endometriosis, irritable bowel syndrome (IBS), carpal tunnel syndrome, temporomandibular joint arthritis (TMJ), vestibulodynia, burning mouth syndrome, diabetic neuropathy, knee osteoarthritis, dysmenorrhea, and regular use of injectable medications for multiple sclerosis showed that PEA may be an effective and well-tolerated treatment for chronic pain.

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Lang-Illievich K, Klivinyi C, Lasser C, Brenna CTA, Szilagyi IS, Bornemann-Cimenti H. Palmitoylethanolamide in the Treatment of Chronic Pain: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials. Nutrients. 2023;

The PEA reduces pain intensity

The following study evaluated the effects of PEA on pain modulation in 14 healthy volunteers using a randomized, double-blind, crossover trial. The results showed that PEA reduced induced pain intensity, improved pain tolerance and conditioned pain modulation, with no adverse effects.

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Klivinyi C, Lang-Illievich K, Rumpold-Seitlinger G, Dorn C, Bornemann-Cimenti H. The Effect of Palmitoylethanolamide on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers—A Randomized, Double-Blinded, Placebo-Controlled Crossover Trial. Nutrients. 2022; 4(19):4084.

The PEA in neuropathic pain

This 2022 study evaluated the safety and efficacy of PEA in 70 patients with diabetic neuropathic pain. After 8 weeks of treatment, PEA reduced pain, improved sleep quality, and decreased systemic inflammation without significant adverse effects.

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Pickering, E., Steels, E. L., Steadman, K. J., Rao, A., & Vitetta, L. A randomized controlled trial assessing the safety and efficacy of palmitoylethanolamide for treating diabetic-related peripheral neuropathic pain. Inflammopharmacology, 2023; 30(6), 2063–2077.